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New Study Demonstrates Brain Differences in People with Borderline Personality Disorder

By October 8, 2008

A recent study has shown that people with Borderline Personality Disorder (BPD) have structural differences in their brains that may account for the intense feelings and difficulties regulating emotions that are key symptoms of BPD.

The study, conducted by researchers at the University of California Davis and Mt. Sinai School of Medicine, demonstrated the the brains of people with BPD had two key differences from those of healthy participants. First, people with BPD had more dense grey matter (working brain tissue) in the part of the brain that creates emotional responses (the amygdala) than healthy controls. The study participants with BPD had another key difference: they had less dense grey matter in a part of the brain that helps to keep emotional responses under control (the anterior cingulate cortex).

Read more about the groundbreaking study from the National Institute of Mental Health Science News site.


Minzenberg MJ, Fan J, New AS, Tang CY, & Siever LJ. "Frontolimbic Structural Changes in Borderline Personality Disorder." Journal of Psychiatric Research, 42:727-733, July 2008.

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